Wilshire Boulevard is one of the principal east-west arterial roads in Los Angeles, California, United States. It was named for Henry Gaylord Wilshire (1861-1927), an Ohio native who made and lost fortunes in real estate, farming, and gold mining.

Running 16 miles from Grand Avenue in Downtown Los Angeles to Ocean Avenue in the City of Santa Monica, Wilshire Boulevard is densely developed throughout most of its span, connecting five of Los Angeles's major business districts to each other, as well as Beverly Hills and Santa Monica downtown. Many of the post-1956 skyscrapers in Los Angeles are located along Wilshire; indeed, one of the oldest and tallest is known simply as "One Wilshire." Aon Center, at one point Los Angeles's largest tower, is at 707 Wilshire Boulevard in Downtown Los Angeles.

One particularly famous stretch of the boulevard between Fairfax and La Brea Avenues is known as the Miracle Mile. The area just to the east of that is referred to as the Park Mile.

All of the boulevard is at least four lanes in width, and most of the portion between Hoover Street and Robertson Boulevard has a raised center median. The widest portion is in the business district of central Westwood, where mobs of pedestrians crossing Wilshire at Westwood Boulevard must traverse ten lanes (including two left-turn pockets). This and the nearby intersection of Wilshire and Veteran are among the busiest in Los Angeles.